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General Category => Bacon, BBQ, Beef, And More => Topic started by: ChrisSmolinski on September 24, 2020, 2117 UTC

Title: Cerebral Fructose Metabolism as Potential Mechanism Driving Alzheimer’s Disease
Post by: ChrisSmolinski on September 24, 2020, 2117 UTC
When fructose metabolism is overactivated systemically, such as from excessive fructose intake, this can lead to obesity and diabetes. Herein, we present evidence that Alzheimer’s disease may be driven by overactivation of cerebral fructose metabolism, in which the source of fructose is largely from endogenous production in the brain. Thus, the reduction in mitochondrial energy production is hampered by neuronal glycolysis that is inadequate, resulting in progressive loss of cerebral energy levels required for neurons to remain functional and viable. In essence, we propose that Alzheimer’s disease is a modern disease driven by changes in dietary lifestyle in which fructose can disrupt cerebral metabolism and neuronal function. Inhibition of intracerebral fructose metabolism could provide a novel way to prevent and treat this disease.

https://www.frontiersin.org/articles/10.3389/fnagi.2020.560865/full