I took a look at the AFE822 schematic. All the power supply circuits seem to be on the same page, I didn't see a DC/DC converter, unless it is lurking elsewhere.
The incoming DC is run through an LM7805, that 5 volts is fed to three linear regulators that produce 1.8 volts, and two 3.3 volt supplies, one for analog and one for digital circuits. The 5 volts from the USB connector is also fed to those regulators, but through a P-channel MOSFET, which is switched off if 5 volts is present from the 7805. So there's some protection in case you apply power to both the DC jack and USB.
There's a fuse and 18V TVS diode on the DC jack, so any voltage above that will be clamped, and eventually you'll open the fuse. There is also a fuse on the USB port power pin.