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Author Topic: High-fructose corn syrup enhances intestinal tumor growth in mice  (Read 294 times)

Offline ChrisSmolinski

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Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

Chris Smolinski
Westminster, MD
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Offline Pigmeat

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Re: High-fructose corn syrup enhances intestinal tumor growth in mice
« Reply #1 on: March 22, 2019, 1156 UTC »
Mice should lay off Miller and Coor's Light.

BTW, do you remember the mutant Moon Mice on "Rocky & Bullwinkle"? They ate TV antenna's. Not many of those left. I hope they don't escape the lab, because they'll be coming straight for our wires.

Offline Josh

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Re: High-fructose corn syrup enhances intestinal tumor growth in mice
« Reply #2 on: March 22, 2019, 1707 UTC »
It's almost as if our "modern" diet and lifestyle has been predicated to be carcinogenic, limiting our lifespans at the same time as enriching those who poison us. Monsatan has been in the news lately for their wonderful carcinogenic insecticide causing cancer, an insecticide that is likely in all our foods now.

Conveniently located near Vincennes Indiana.