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Author Topic: The Effects of High-Fat or High-Carbohydrate Diet on Intramyocellular Lipids  (Read 2676 times)

Offline ChrisSmolinski

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This confirms the idea that the modern high carbohydrate diet is a contributing factor to the increase in insulin resistance, which then leads to type 2 diabetes. Also that the high fat diet improved lipid (cholesterol) numbers.

The Effects of High-Fat or High-Carbohydrate Diet on Intramyocellular Lipids

We concluded that 4 weeks of high-carb diet, with no weight change, increased fasting insulinaemia and TA IMCL with a trend to increase insulin resistance with no changes in lipids in a population of women without metabolic syndrome. This effect was not reversible after a 5% body weight loss over eight weeks. We also found that 4 weeks of high-fat diet (79% with mono and polyunsaturated fat), without altering body weight, did not modify insulinaemia, IMCL or insulin resistance, improved lipid profile increasing HDL-C and decreasing TG. Both diets promoted similar weight loss. Since this is the first trial to study the effects of diet composition, over weeks, in a female group without metabolic syndrome, we believe that future trials are necessary to better understand the role of diet composition on IMCL deposits and insulin resistance.Declaration of Competing Interests: Nothing to declare.

Chris Smolinski
Westminster, MD
eQSLs appreciated! csmolinski@blackcatsystems.com
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